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Cancer of the Skin: Expert Consult – Online and Print, 2nd edition edited by Darrell S. Rigel, MD, June K. Robinson, MD, Merrick I. Ross, MD, Robert J. Friedman, MD, MSc (Med), Clay J. Cockerell, MD, Henry W. Lim, MD, Eggert Stockfleth, MD, PhD, & John M. Kirkwood, MD (Elsevier Saunders) Skin cancer rates are rising dramatically. In the United States each year there are over 2 million newly diagnosed cases – more than all other cancers combined. The public health ramifications are profound. Skin cancer, once viewed as a relatively uncommon disease limited to dermatologists and surgeons, is now being seen on a daily basis by primary care physicians, oncologists and other healthcare professionals. The resulting need to educate all of these groups on recognizing and managing patients with this cancer is also increasing.

Online and in print, Cancer of the Skin, edited by Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is clinicians’ complete, multimedia guide to early diagnosis and medical and surgical treatment of melanoma and other skin cancers. Thoroughly updated with 11 new chapters, this broad-based, comprehensive reference provides clinicians with the latest information on clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other timely topics. A new, multi-disciplinary team of contributors and editors comprised of leading experts in the field offers diverse perspectives and worldwide best practices. The complete text – including 900 full-color, downloadable images and 6 procedural videos – can be accessed online.

With Cancer of the Skin clinicians are able to:

  • Broaden their understanding of all aspects of skin cancer – from the underlying biology to clinical manifestations of the disease to diagnosis, and medical and surgical treatment – with this multimedia reference.
  • See conditions as they appear in practice with guidance from detailed full-color images and step-by-step procedural videos.
  • Stay current with the latest advancements and therapies.
  • Get diverse perspectives and worldwide best practices from a multi-disciplinary team of contributors comprised of leading experts.
  • Access the complete text online – including image bank and video library.
  • Diagnose skin cancer effectively using a multimedia reference with a multi-disciplinary approach and the latest content and techniques.

Editors of Cancer of the Skin, 2nd edition and their credentials are: Darrell S. Rigel, MD, Clinical Professor of Dermatology, New York University Medical Center, New York; June K. Robinson, MD, Professor of Clinical Dermatology, Feinberg School of Medicine, Northwestern University, Chicago; Merrick Ross, MD, Professor of Surgery, Chief, Melanoma Section, Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center, Houston; Robert J. Friedman, MD, MSc (Med), Clinical Professor, Department of Dermatology; New York University School of Medicine, New York; Clay J. Cockerell, MD, Clinical Professor, Dermatology and Pathology; Director, Cockerell and Associates Dermpath Diagnostics; Director, Division of Dermatopathology, University of Texas, Southwestern Medical Center, Dallas; Henry W. Lim, MD, Chairman and C. S. Livingood Chair, Department of Dermatology, Henry Ford Hospital, Senior Vice President for Academic Affairs, Henry Ford Health System, Detroit; Eggert Stockfleth, MD, PhD, Professor of Dermatology, Head of Skin Cancer Center Charité, Vice-chair of Department of Dermatology, Venereology and Allergy Charité – University Medical Center Berlin, Berlin; and John M. Kirkwood, MD, Usher Professor of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine, Director, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh.

Contents of Cancer of the Skin include:

Part 1: Basic skin cancer biology and epidemiology

  1. The Biology of Skin Cancer Invasion and Metastasis – Ricardo L. Berrios and Jack L. Arbiser
  2. Genetics of Skin Cancer – Oscar R. Colegio and David J. Leffell
  3. The Biology of the Melanocyte – Julie V. Schaffer and Jean L. Bolognia
  4. Skin Cancer: Burden of Disease – Abrar Qureshi
  5. Epidemiology of Skin Cancer – Melody J. Eide and Martin A. Weinstock
  6. Etiological Factors in Skin Cancers: Environmental and Biological – Luigi Naldi, Drusilla Hufford, and Luke Hall-Jordan
  7. The Importance of Primary and Secondary Prevention Programs for Skin Cancer – June K. Robinson
  8. Chemoprevention of Skin Cancers – Marie-France Demierre and Michael Krathen
  9. Current Concepts in Photoprotection – Christopher T. Burnett, Darrell S. Rigel, and Henry W. Lim

Part 2: Non-melanoma

  1. Actinic Keratoses and Other Precursors of Keratinocytic Cutaneous Malignancies – Christina L. Warner and Clay J. Cockerell
  2. Basal Cell Carcinoma – Clay J. Cockerell, Kien T. Tran, John Carucci, Emily Tierney, Pearon Lang, John C. Maize Sr., and Darrell S. Rigel
  3. Squamous Cell Carcinoma – Sanjay Bhambri, Scott Dinehart, and Avani Bhambri
  4. Adnexal Carcinomas of the Skin – Sarah N. Walsh and Daniel J. Santa Cruz
  5. Paget's Disease – Gagik Oganesyan, S. Brian Jiang, and Dirk M. Elston
  6. Sarcomas of the Skin – Tawnya L. Bowles, Merrick I. Ross, and Alexander J. Lazar
  7. Kaposi's Sarcoma – Miguel Sanchez
  8. Merkel Cell Carcinoma – Jayasri G. Iyer, Renee Thibodeau, and Paul Nghiem
  9. Malignant Neoplasms: Vascular Differentiation – Omar P. Sangueza and Luis C. Recquena
  10. Cutaneous Neoplastic Disorders Related to HPV and HIV Infection – Kien T. Tran, Jane M. Grant-Kels, and Clay J. Cockerell
  11. Pseudolymphomas of the Skin – Lorenzo Cerroni and Helmut Kerl
  12. Cutaneous T-cell Lymphoma: Mycosis Fungoides and Sezary Syndrome – Brittany A. Zwischenberger, Amit G. Pandya, and Joan Guitart

Part 3: Melanoma and related melanocytic neoplasms

  1. Dysplastic Nevi – Holly Kanavy, Jennifer A. Stein, Edward Heilman, Michael K. Miller, David Poisky, and Robert J. Friedman
  2. Congenital Melanocytic Nevi – Julie V Schaffer, Harper N. Price, and Seth J. Orlow
  3. The Many Faces of Melanoma – Darrell S. Rigel
  4. The Importance of Early Detection of Melanoma, Physician and Self-Examination – Julie E. Russak, Darrell S. Rigel, and Robert J. Friedman
  5. Prognostic Factors and Staging in Melanoma – Jeffrey E. Gershenwald
  6. Pathology of Melanoma: Interpretation and New Concepts – Carlos Ricotti, Jennifer Cather, and Clay J. Cockerell
  7. Management of the Patient with Melanoma – Jacqueline M. Goulart and Allan C. Halpern
  8. Pregnancy and Melanoma – Marcia S. Driscoll and Jane M. Grant-Kels
  9. Genetic Testing for Melanoma – Wendy Kohlmann and Sancy A. Leachman

Part 4: Other cancers of the skin and related issues

  1. Spitz Nevus – Philip E. LeBoit
  2. Cutaneous Carcinogenesis Related to Dermatologic Therapy – Rebecca Kleinerman, Allison P. Weinkle, and Mark G. Lebwohl
  3. Genetic Disorders Predisposing to Skin Malignancy – Courtney Schadt and Jo-David Fine
  4. Dermatologic Manifestations of Internal Malignancy – Diana D. Antonovich, Bruce H. Thiers, and Jeffrey P. Callen
  5. Dermatologic Manifestations of Systemic Oncologic Therapy of Cutaneous Malignancies – Beth McLellan, Caroline Robert, and Mario E. Lacouture

Part 5: New approaches

  1. The Dermoscopic Patterns of Melanoma and Non-Melanoma Skin Cancer – Steven Q. Wang, Margaret C. Oliviero, and Harold S. Rabinovitz
  2. Computer-Aided Diagnosis for Cutaneous Melanoma – Sallyann Coleman King, Clara Curiel-Lewandowski, and Suephy C. Chen
  3. Confocal Microscopy in Skin Cancer – Verena Ahlgrimm-Siess, Harold S. Rabinovitz, Margaret Oliviero, Rainer Hofmann-Wellenhof, Ashfaq A. Marghoob, Salvador Gonzalez, and Alon Scope
  4. Clinical Genomics for Melanoma Detection – William Wachsman

Part 6: Therapeutic considerations in the management of patients with cancer of the skin

  1. Biopsy Techniques – Joseph F Sobanko, Justin J. Leitenberger, Neil A. Swanson, and Ken K. Lee
  2. Curettage and Electrodesiccation – Samuel F. Almquist, Oliver J. Wisco, and J. Michael Wentzell
  3. Cryosurgery – Paola Pasquali
  4. Topical Treatment of Skin Cancer – Victoria Williams, Theodore Rosen, Roger I. Ceilley, James Q. del Rosso, and Eggert Stockfleth
  5. Immune Response Modulators in the Treatment of Skin Cancer – Brian Berman, Martha Viera, Sadegh Amini, and Whitney Valins
  6. Photodynamic Therapy in Skin Cancer – Colin A. Morton
  7. Surgical Excision for Non-Melanoma Skin Cancer – Sherrif F. Ibrahim and Marc D. Brown
  8. Mohs Surgery – Edward Upjohn and R. Stan Taylor
  9. Treatment of Disseminated Non-Melanoma Skin Cancers – Kathryn A. Gold and Merrill S. Kies
  10. Surgical Excision of Melanoma – Robert H.I. Andtbacka
  11. Regional Lymph Node Surgery in Melanoma Patients – Merrick I. Ross
  12. Reconstructive Surgery for Skin Cancer – Justin M. Sacks, Kriti Mohan, and Donald Baumann
  13. Radiation Therapy in the Treatment of Skin Cancers – Jay S. Cooper
  14. Adjuvant Therapy for Cutaneous Melanoma – Ahmad A. Tarhini, Stergios J. Moschos, and John M. Kirkwood
  15. Vaccine Therapy for Melanoma – Amod A. Sarnaik, Nasreen Vohra, Shari Pilon-Thomas, and Vernon K. Sondak
  16. Targeted Therapy for Melanoma – Stergios Moschos
  17. Imaging Work-up of the Patient with Melanoma – Hussein Tawbi and John M. Kirkwood
  18. Treatment of Disseminated Melanoma – Jason L. Chang, Patrick A. Ott, and Anna C. Pavlick
  19. Management of Skin Cancer in the Immuno-compromised Patient – Thomas Stasko, Allison Hanlon, and Anna Clayton

Part 7: Other aspects of skin cancer

  1. Indoor Tanning – James M. Spencer and Darrell S. Rigel
  2. Vitamin D and UV: Risks and Benefits – Henry W. Urn, Wenfei Xie, and Darrell S. Rigel
  3. Photography in Skin Cancer Treatment – Bill Witmer and Peter Lebovitz
  4. Psychological Responses and Coping Strategies in Skin Cancer Patients – Nadine Angele Kasparian and Phyllis Nancy Butow
  5. Medical and Legal Aspects of Skin Cancer Patients – Abel Torres, Clay Cockerell, Jamison Strahan, and Tanya Nino

It is now over two decades ago that the seminal comprehensive text Cancer of the Skin was published. Cancer of the Skin is an update on the enormous progress that has been made on all levels, including clinical, therapeutic, epidemiologic, genetic and histopathologic, and on all levels of basic sciences with emphasis on neoplastic cellular biology.

A broad array of cancers of the skin is included in this comprehensive work. Special emphasis is placed on those cutaneous cancers that are particularly prevalent (e.g. basal cell carcinoma) and those which are responsible for the highest number of fatalities (e.g. melanoma and squamous cell carcinoma).

All of the clinical images are published in full color and of the highest quality. Major emphasis is placed on the diagnosis and man­agement of cutaneous malignancies so that readers are provided with the most advanced diagnostic and therapeutic measures available to date for each type of skin cancer.

The advances that have occurred even in the past decade alone in our understanding of the basic biology, genetics, diagnosis, and treatment of skin cancer have been staggering. In sitting down to review the layout of Cancer of the Skin, the editors say they were amazed at the multitude of topics that had changed extensively or did not even exist for inclusion in the prior edition of the book. The advent of dermoscopy, confocal microscopy, computer-aided diagnosis, digital photographic documentation, topical immune response modulators, and advances in immunotherapy, lymph node biopsies, photoprotection agents and our understanding of the biologic basis of this cancer all demonstrate the incredible dynamism of this field. Social issues that have arisen such as genetic testing and the deleterious effects of tanning salons also emphasize the need to understand this cancer within a broader context. All of these topics are covered in depth in Cancer of the Skin to facilitate a wide-ranging understanding of skin neoplasms.

Primary prevention efforts are also becoming increasingly important. Skin cancer is one of the few cancers where we know the cause of the vast majority of neoplasms – excess ultraviolet exposure whether from the sun or artificial sources. Simple behavioral changes can lead to a significant decrease in a person's chance of developing skin cancer. An understanding of the mechanisms and risk factors of skin cancer are critical in counseling patients to facilitate prevention. Skin cancer is also one of the most clear-cut cases of a disease where early detection and treatment are critical. Skin cancers treated early are virtually 100% curable with simple therapies, while lesions that are advanced often have no effective treatment available. Therefore, the need for medical practitioners to be able to recognize and treat skin cancer in its earliest phase cannot be overstated.

The changing demographics of skin cancer have also led to a need to focus prevention efforts on subsets of the population and to alter therapy for these groups. The editors meet this need through providing information on such topics as the management of melanoma in the pregnant patient. To develop an inclusive understanding of skin cancer, one must remember that there are more than basal and squamous cell carcinoma and melanoma. Cancer of the Skin provides an inclusive review of precursor lesions, other non-melanoma skin cancers and cutaneous neoplasms related to other disorders.

This book is an excellent primary resource for any physician seeking reliable and accessible information on cancer of the skin. It will also serve as a valuable ancillary resource for practitioners whose clinical duties involve the management of skin cancer, because it provides a thorough understanding of the biologic behavior, clinical presentation, and current treatment of malignant diseases of the skin. – NEJM, review of last edition

The backbone of Cancer of the Skin is the many authors whose broad experience in cutaneous etiology, and the therapeutic guidelines they have documented are valuable assets to any individual involved in the multi-disciplinary needs of these patients. Thus, Cancer of the Skin serves as a valuable resource not only to physicians but also to all others who deal with the consequences of malignant tumors of the skin. Clinicians will find this comprehensive textbook a valuable summary of the current knowledge gleaned by the literally thousands of years of combined clinical and therapeutic experience coupled with extensive reviews of literature by the multiple authors who have the very best of what is known today.

The volume meets the needs of practitioners in a format that is conducive to effectively transmitting relevant data to readers. Through the use of representative color clinical images, photomicrographs and flow diagrams, information on diagnosing and treating skin cancer is portrayed in an easy-to-understand manner.

Treatment of Skin Disease: Comprehensive Therapeutic Strategies edited by Mark G. Lebwohl, Warren R. Heymann, John Berth-Jones, & Ian Coulson (Mosby, Elsevier Science) Treatment of Skin Disease, PDA Version: Comprehensive Therapeutic Strategies (CD-ROM) edited by Mark G. Lebwohl, Warren R. Heymann, John Berth-Jones, & Ian Coulson (Mosby, Elsevier Science) “Now what do I do?” <>

The clinician has to address this question on a daily basis when faced with a patient who is not responding to usual treat­ments. The goal of Treatment of Skin Disease is to help the frustrated physician solve the problem by providing access to an authoritative overview and a succinct, clinically-oriented summary of the rel­evant literature.

This book provides therapeutic strategies and treatment advice for over 200 dermatologic diseases encountered by the clinician. It is organized alphabetically and designed for immediate and quick reference. Treatment of Skin Disease covers both standard and difficult clinical problems, with the focus on therapeutically challenging conditions. A summary of the management strategy for each disease is given. This is followed by primary, secondary and tertiary treatment options and the evidence base for each of them. Throughout the book, the treatment recommendations are ranked according to evidence of efficacy. Most references are annotated with observations from the author team. In addition, each condition is illustrated with a representative color photograph to provide a diagnostic reminder.

Most of the roughly 300 authors are leading authorities in their fields of expertise, and all offer the most comprehensive and accurate information available.

A distinct feature of Treatment of Skin Disease is that the level of evidence sup­porting each treatment is summarized in each chapter. This is a unique systematic summary of the evidence base for the entire specialty of dermatology. Aficionados of ‘evidence-based medicine’ may be dismayed to learn that, in the opinions of the authors, in only 81 out of 213 chapters is there even a single ideally designed, placebo-controlled trial of any treatment (that is, one treatment with evidence grade A). Even in these chapters, many of the first line treatments are lacking such evidence. In another 51 chapters there is at least one treatment for which the efficacy is evidenced by at least one trial although this is considered to be lacking adequate controls or to be sub­optimal in design (evidence grade B). In another 38 chapters there is at least one treatment supported by a small trial with less than 20 subjects or for which there are large numbers of case reports (evidence grade C). In the remaining 43 chapters the only evidence base available for any treatment at all comprises uncon­trolled reports of small numbers of patients responding. The editors hope that Treatment of Skin Disease will increase awareness of the lack of evi­dence available to support many treatments. Perhaps the book will stimulate industrious colleagues to rise to the challenge of providing the first trial of a treatment for pitted keratolysis, juve­nile plantar dermatosis, pityriasis lichenoides or porokeratosis.

The editors point out that even as this text goes to press, they realize that newer and better treatments are being developed. The steady stream of new dermatologic therapies will hopefully continue to justify more and more books on the treatment of dermatologic disease.

The PDA version: With Treatment of Skin Disease, PDA Version loaded on a handheld device, the physician has portable, instant access to the most important primary, secondary, and tertiary treatments for over 200 therapeutically challenging dermatologic disorders. For each condition, the reader will find a full-color photograph, plus bulleted summaries of

  • Key facts
  • Management strategies
  • Specific investigations
  • Primary therapies
  • Secondary therapies
  • Tertiary therapies.

Organized alphabetically by disease type, these treatment recommendations offer the physician all the specific, evidence-based guidance needed in a quick-reference format.
Both versions have been edited by Mark Lebwohl, MD, Sol and Clara Kest Professor, Chairman of Dermatology, Mt. Sinai Hospital, Mt. Sinai, NY; Warren Heymann, MD, Head of Division of Dermatology, Robert Wood Johnson Medical School, Camden, NJ; John Berth-Jones, FRCP, Consultant Dermatologist, Walsgrave Hospital, Coventry, UK; and Ian Coulson, FRCP, Consultant Dermatologist, Burnley General Hospital, Burnley, UK.

The therapeutic knowledge of nearly 300 dermatologists has been distilled in these volumes Treatment of Skin Disease. They provide an invaluable guide to treatment options and strategies for the dermatologist, primary care physician, and all clinicians involved in the care of patients with skin disease.


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