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The Handbook Of Clinically Tested Herbal Remedies, Two Volume Set edited by Marilyn Barrett (Haworth Herbal Press) A single source for accurate scientific information on herbal remedies!

The Handbook of Clinically Tested Herbal Remedies is the reference tool you need to distinguish those herbal products that have been clinically tested from those for which there is little or no real evidence that substantiates or disputes their claims of efficacy. This essential volume provides a snapshot of 160 herbal products that have been tested in clinical trials. Details of the products and the clinical trials they underwent are here in an easy-to-read, at-a-glance format.

Each botanical profile in The Handbook of Clinically Tested Herbal Remedies contains a summary section (table, text and references), followed by product information and clinical trials for that particular product. An evaluation of the strength of the evidence from the trials, along with the context for therapeutics is included to give you a complete picture of each remedy and its usefulness or lack thereof. If there is more than one product based on a particular botanical then the trials are grouped according to the product.

This valuable book also makes purchasing easy with manufacturer contact information. With over 30 individual botanicals and 10 multi-ingredient formulas, 160 products and 360 clinical studies, The Handbook of Clinically Tested Herbal Remedies is the book you need to make an informed selection of herbal products. Not only does it list proprietary herbal products that have been tested in controlled clinical studies and provide a rating of the quality of those trials, but, it also describes the fundamentals of herbal medicine, including regulation, characterization, standardization, bioavailability, efficacy, safety, pharmacopoeial monographs as well as incentives, or lack of incentive, for US and European manufacturers to conduct clinical studies.

Contributors to the chapters describing the fundamentals of herbal medicine include:

the late Dr. Varro Tyler, Distinguished Professor Emeritus at Purdue University and co-author of Tyler’s Honest Herbal, Rational Phytotherapy, and Tyler’s Herbs of Choice

Loren Israelsen, JD, president of the LDI group

Tieraona Low Dog, MD, Chair of the USP Dietary Supplement Information Committee

Joerg Grünwald, PhD, co-author of the Physicians Desk Reference (PDR) for Herbal Medicines, and Stefan Spiess, RPh, President of Grünwalder GmbH

Anton Biber, PhD, and Friedrich Lang, PhD, experts in the bioavailability of herbal medicine at Dr. Willmar Schwabe GmbH & Co., Germany

Anthony Almada, MSc, founder and Chief Scientific Officer of IMAGINutrition, Inc.

Joseph M. Betz, PhD, Director of the Dietary Supplements Methods and Reference Materials Program at the NIH Office of Dietary Supplements

Ezra Bejar, PhD, president of Plant Bioassay

Uwe Koetter, PhD, Director of New OTC and Dietary Supplement Product Development at GlaxoSmithKline

Srini Srinivasan, PhD, Vice President of the Dietary Supplement Verification Program of the United States Pharmacopeia (USP)

Roy Upton, Executive Director of the American Herbal Pharmacopoeia.

All of the clinical trials in The Handbook of Clinically Tested Herbal Remedies were rated as to their Level of Evidence according to a system designed by Tieraona Low Dog, MD, Chair of the United States Pharmacopoeia Dietary Supplements/Botanicals Expert Panel and a member of the White House Commission on Complementary and Alternative Medicine. The reviewers of the clinical trials included Karriem Ali, MD; Richard Aranda, MD; Elliot Fagelman, MD; Mary Hardy, MD; David Heber, MD, PhD, FACP, FACN; John Trimmer Hicks, MD, FACP, FACR; Hannah Kim, MD; Franklin C. Lowe, MD, MPH; Richard D. O’Connor, MD; Barry S. Oken, M.D; Lynn Shinto, ND; and Keith Wesnes, PhD.

This book provides consumers and health professionals with a means to distinguish those herbal products that have the backing of clinical evidence to substantiate claims of efficacy. It includes product descriptions provided largely from label information. In addition, this book describes in detail the trials associated with those products and provides an assessment of the quality of those trials.

Only products that have undergone controlled clinical trials are included, as this research design is considered the most persuasive and is generally given the most weight by researchers and practitioners. Many herbal preparations commonly sold on the market are not included in this text, as they have not been subjected to controlled clinical trials.

The book lists products, made with 32 herbs and ten formulas, that have been studied in a total of 369 clinical trials. Attempts were made to be systematic and inclusive in gathering products and trials; how-ever, due to the magnitude of the effort and the amount of time required to complete the project, I acknowledge that it is essentially a snapshot—a sampling of the existing products and their clinical trials at the time when we were doing research for the book.

It is my hope that this snapshot will assist in the evaluation of the clinical science behind botanical medicine and will help with the evaluation of the evidence for herbal product efficacy. I also hope that this book will help to bridge the gap between herbal medicine and standard Western therapies by using the language of the latter to de-scribe the former. Ultimately it is my desire that this book will assist in establishing an appropriate place for botanical medicine alongside standard Western therapies in the medicine cabinet.

The chapters in Part I: Fundamentals of Herbal Medicine provide background as well as context for the product and trial summaries that follow. These chapters provide information on the regulatory status of botanicals in the United States, the characterization and standardization of products, as well as the means to establish bioavailability, efficacy, and safety. Also included is a discussion on the "borrowing" of science from one product to support claims of efficacy for another. In addition, there is a discourse on the motives for conducting trials in the United States and in Europe, particularly in Germany. Finally, a chapter on pharmacopoeial monographs de-scribes what they are and what information they provide.

Part II: Methods describes the methods used to gather information on products and clinical studies. It includes the criteria for entry into the book and the means used to evaluate the efficacy of the individual trials.

Part III: Botanical Profiles contains information on products and clinical trials. Most of Volume Two is filled with the data. Products are grouped according to the principal botanical ingredient. If the products are multi-ingredient formulas, without a primary ingredient, then they are listed separately. Each botanical section is headed by a summary review of the products and trials. This summary section contains an at-a-glance table listing the products included in that section, the indications addressed by the clinical studies, and the number and quality of those studies. The summary section also includes information from therapeutic monographs with use information for that herb. The summary section is followed by details on the products, which is in turn followed by a detailed account of the clinical trials for each product.

Indexes allow for easy access to the product and trial information through the botanical common and scientific names, as well as by product and manufacturer names and therapeutic indication.

Series Medicinal and Aromatic Plants ‑ Industrial Profiles Series Editor Roland Hardman, BPharm BSc (Chemistry) PhD (London) FRPharmS, has had experience in retail, industrial and academic pharmacy. He has held academic posts in universities in Nottingham, UK; Ibadan, Nigeria (Head of the Pharmacy Department); and Bath, UK (Reader and Head of Pharmacognosy) and is now retired. He has over 150 research and related publications to his name and Dr Hardman has also held patents on the processing of plants and Plant Breeders' Rights. For some years he represented the UK on the committee for the Utilization of Medicinal and Aromatic Plants of the Economic Union and from 1988‑1995 he was the President of the Section for Study of Medicinal and Aromatic Plants of the Federation Internationale Pbarmaceutigue. Dr Hardman keeps in touch with the latest developments in the field through his work as a consultant.

Individual volumes in the series Medicinal and Aromatic Plants ‑ Industrial Profiles provide both industry and academia with in‑depth coverage of the major medicinal and aromatic plants of industrial importance in a genus. Each volume will discuss key topics such as plant sources and their commercial cultivation, chemical constituents, quality assurance, pharmacological properties, toxicology, application and market trends relevant to the genus.

The series will be of great value to those engaged in botany, agriculture, pharmacognosy, phytochemistry, the food, flavor, cosmetic and fragrance industries, alternative medicine and in other pharmaceutical and health sciences

Mistletoe: The Genus Viscum edited by Arndt Bussing (Medicinal and Aromatic Plants: Industrial Profiles: Harwood Academic Publishers) Mistletoe is the 16th volume in the series Medicinal and Aromatic Plants ‑ Industrial Profiles. Viscum album has been used as a remedy for at least 2,000 years, nowadays predominantly in complementary cancer therapy. Despite an obvious discrepancy between the popularity of mistletoe extracts and their classification as a non‑conventional treatment modality with unproven efficacy in oncology, mistletoe is one of the most widely used adjuvant treatments of neoplastic disorders, especially in German speaking areas. This book contains a series of expert dissertations on mistletoes from Africa, Argentina, Europe and Korea, history, cultivation, development and processing, description of relevant compounds, pharmacology and toxicology, and current market trends, i.e. development of a recombinant toxic lectin from Viscum album.

This book provides a comprehensive overview of current knowledge in mistletoe use from well recognised researchers from Argentina, England, Greece, Korea, Switzerland, USA and Germany, and will be an invaluable reference source for anyone with an interest in the wide range of applications of this plant and its therapeutic potential in cancer therapy.

About the Editor

Arndt Bussing received his medical degree from the Technical University Aachen in 1992. He started his research on plants in immunology and oncology in the Institute of Medical Immunology at the Technical University Aachen and became head of the Department of Applied Immunology at the foundation `Krebsforschung Herdecke', University WittenlHerdecke. In 1996, he received the Hartmut‑Franz‑Prize for his research on the immunological effects of mistletoe. Today, he is one of the outstanding experts on the growing field of mistletoe research. 

Sage: The Genus Salvia edited by S. E. Kintzios (Medicinal and Aromatic Plants: Industrial Profiles: Harwood Academic Publishers) Scholars of botany, medicine, biotechnology, and related fields explore the constituents and processes by which members of one of the most widely spread and used plant genus can be turned into commercial products. After listing the 400 or so best known species and identifying their folklore and cosmetic use, they cover botany, chemical constituents, cultivation and breeding, pharmacology, biotechnology, commercial aspects, and general issues. Among specific topics are salvianolic acids and related compounds, genetic improvements of cultivated species, antioxidants from Salvia officinalis, in vitro rosmarinic acid production, and the production of Salvia oil in Mediterranean countries.

Sage, the genus Salvia is one of the most famous and used herbs in the world. This volume, containing twenty chapters written by the leading experts in the field, presents a comprehensive coverage on all aspects of Salvia. Topics covered include the presentation of the (approximately 400) most known Salvia species; the distribution of the genus; its chemotaxonomy, ecophysiology, cultivation technology and breeding methods; information on the extraction, isolation, characterisation and structure of a large number of bioactive components the various pharmacological properties of the species; the share of Salvia products in the aromatherapy and natural cosmetics market; biotechnological techniques; and commercial aspects.

This comprehensive volume on Salvia should be of interest to everyone involved in medicinal and aromatic plant applications and research.

About the Editor

Spiridon E. Kintzios is a senior lecturer at the Department of Plant Physiology in the Faculty of Agricultural Biotechnology of the Agricultural University of Athens, Greece. After gaining his degree as an agricultural engineer, he conducted research on viroids at the Max Planck Institute for Biochemistry in Munich, Germanv. In 1993 he received his PhD in Plant Breeding and Genetics from the Technical University of Munich, Weihenstcphan and in the same year lie was elected to his present position, as coordinator of the plant tissue culture research group. His main research interests lie in the field of somatic embrvogenesis and synthetic seed production of various medicinal, horticultural and ornamental species as well as the production of medicinal secondary metabolites from plant cell cultures.

 

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